Salmonella-based Vaccine to Combat Fatal Diseases
Tempe, AZ (Scicasts) - A powerful new class of therapeutics, known as recombinant attenuated Salmonella vaccines (RASV), holds great potential in the fight against fatal diseases including hepatitis B, tuberculosis, cholera, typhoid fever, AIDS and pneumonia.
According to the report from Arizona State University, researcher Qingke Kong and his colleagues at the Biodesign Institute, have developed a technique to make such vaccines safer and more effective. The group, under the direction of Dr. Roy Curtiss, chief scientist at Biodesign's Center for Infectious Diseases and Vaccinology, demonstrated that a modified strain of Salmonella showed a five-fold reduction in virulence in mice, while preserving strong immunogenic properties.
Their findings appear in the cover story of the current issue of the Journal of Immunology.
Streptococcus pneumoniae, an aerobic bacterium, is the causative agent of diseases including community-acquired pneumonia, otitis media, meningitis, and bacteremia. It remains a leading killer—childhood pneumonia alone causing some 3 million fatalities annually, mostly in poorer countries.
Existing vaccines are inadequate for protecting vulnerable populations for several reasons. Heat stabilization and needle injection are required, which are often impractical for mass inoculation efforts in the developing world. Repeated doses are also needed to induce full immunity. Finally, the prohibitively high costs of existing vaccines often deprive those who need them most. The problem is exacerbated by the recent emergence of antibiotic-resistant strains of pneumococcus causing the disease, highlighting the urgency of developing safe, effective, and lower-cost antipneumococcal vaccines. One of the most promising strategies for new vaccine development is to use a given pathogen as a cargo ship to deliver key antigens from the pathogen researchers wish to vaccinate against. Salmonella, the bacterium responsible for food poisoning, has proven particularly attractive for this purpose, as Curtiss explains: "Orally-administered RASVs stimulate all three branches of the immune system stimulating mucosal, humoral, and cellular immunity that will be protective, in this case, against a majority of pneumococcal strains causing disease." Recombinant Salmonella is a highly versatile vector—capable of delivering disease-causing antigens originating from viruses, bacteria and parasites. An attenuated Salmonella vaccine against pneumonia, developed in the Curtiss lab, is currently in FDA phase 1 clinical trials.
Typhoid Fever Symptoms Disease - News
Tempe, AZ (Scicasts) - A powerful new class of therapeutics, known as recombinant attenuated Salmonella vaccines (RASV), holds great potential in the fight against fatal diseases including hepatitis B, tuberculosis, cholera, typhoid fever,
Existing vaccines are inadequate for protecting vulnerable populations against fatal diseases, including hepatitis B, tuberculosis, cholera, typhoid fever, AIDS and pneumonia. Now, Qingke Kong and his colleagues at the Biodesign Institute at Arizona
Signs and symptoms of salmonellosis - of the thousands of Salmonella types, only about 12 make people ill. Some can cause typhoid fever, a potentially serious and even fatal disease, especially in developing nations.
He also was diagnosed with bipolar disorder, and five years ago contracted Typhoid Fever, which may have damaged his heart. Prior to his death, Irons had been suffering from severe flu-like symptoms while at the Rip Curl Search in Puerto Rico and
(See the article on typhoid fever) E. coli. The full name of this bacterium is Escherichia coli (E. coli). Both harmless and disease-causing strains of this organism are found in the intestinal tracts of animals and humans.
Do Not Underestimate Symptoms of Typhoid ~ GN World
&Nbsp;According to Djoko, typhoid fever primarily affects the heads at productive age. At that age, a person eat more meals exterior the at rest thence that cleanliness is not guaranteed. Bacteria Salmonella typhi, the effect of typhoid can enter the body completed food and beverages consumed by a person. Germs will get into the intestines and multiply.
Typhoid Fever Symptoms Disease - Bookshelf
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I have never known a case of typhoid fever cut short by any remedial agent ... but that by the time the first symptoms of the disease occur the nervous ...JAMA., The Journal of the American Medical Association
She presented fairly well-marked symptoms of typhoid fever, except that the tenderness and pain in the right iliac fossae seemed to justify a graver disease ...Science
The difficulties lie in the fact that typhoid-fever is frequently a very mild disease, with few of the characteristic symptoms ; and that sometimes the ...The Medical news
During the season of maximal prevalence of typhoid fever many cases presenting symptoms ordinarily quite distinct from this disease will prove if submitted ...Typhoid fever; its causation, transmission and prevention
Typhoid fever, or enteric fever, is an intestinal disease, ... are produced in various parts which give rise to the characteristic symptoms of the disease. ...Day-by-day Posts Directory
Typhoid Fever - CDC
... threatening illness including steps for avoiding it, vaccination info, common symptoms, and treatment. From the Centers for Disease Control and Prevention. ...
Typhoid Fever Signs and Symptoms - MayoClinic
Typhoid fever — Comprehensive overview covers symptoms, treatment of this serious intestinal illness.
Typhoid Fever - Symptoms, Diagnosis, Treatment of Typhoid ...
Typhoid fever is a bacterial infection characterized by diarrhea, systemic disease, and a ... Early symptoms are generalized and include fever, malaise and ...
Typhoid Fever Symptoms
Common symptoms of typhoid fever include muscle weakness, a characteristic rash, and decreased heart rate. This eMedTV segment discusses mild and ...
Typhoid fever - Wikipedia, the free encyclopedia
For a related disease which is caused by two different bacteria, see Paratyphoid fever. For the character in the 2006 film Elektra, see Typhoid (Elektra) ...